A rigid bicyclic ketene was used to generate highly constrained polycyclic spiro-β-lactams through the Staudinger reaction. Depending on the imine component, high diastereoselectivity was observed in the process, leading to mainly the cis diastereoisomer in the case of aromatic imines. This results from an anti addition of the imine to the ketene, followed by a conrotatory ring closure in which the heteroatom at the 6-position of the scaffold rotates outward because of torquoelectronic effects.
Diastereoselective synthesis of highly constrained spiro-β-lactams via the Staudinger reaction using an unsymmetrical bicyclic ketene / Trabocchi, Andrea; Lalli, C.; Guarna, F.; Guarna, Antonio. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - STAMPA. - -:(2007), pp. 4594-4599. [10.1002/ejoc.200700260]
Diastereoselective synthesis of highly constrained spiro-β-lactams via the Staudinger reaction using an unsymmetrical bicyclic ketene
TRABOCCHI, ANDREA;GUARNA, ANTONIO
2007
Abstract
A rigid bicyclic ketene was used to generate highly constrained polycyclic spiro-β-lactams through the Staudinger reaction. Depending on the imine component, high diastereoselectivity was observed in the process, leading to mainly the cis diastereoisomer in the case of aromatic imines. This results from an anti addition of the imine to the ketene, followed by a conrotatory ring closure in which the heteroatom at the 6-position of the scaffold rotates outward because of torquoelectronic effects.File | Dimensione | Formato | |
---|---|---|---|
Spiro - EJOC2007.pdf
Accesso chiuso
Tipologia:
Pdf editoriale (Version of record)
Licenza:
Tutti i diritti riservati
Dimensione
156.28 kB
Formato
Adobe PDF
|
156.28 kB | Adobe PDF | Richiedi una copia |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.