Interlaboratory reproducibility of isoelectric focusing in oligoclonal band detection

Data from our previous OCB quality control survey showed that participating centers concurred in OCB-positive and OCB-negative sample identification, but differed in the numbers of OCBs found, We assumed that this lack of reproducibility could lead to false-negative/positive results in critical CSF samples, i.e., samples with few and weak bands. Accordingly, we aimed to produce a more comprehensive survey by involving more centers and by including critical samples.