We previously demonstrated that adult rats prenatally exposed to ethanol display permanent damages of thalamo-cortical connections [18,19,33]. Here the effect of simultaneous administration of ethanol and acetyl- l-carnitine has been investigated. Adult animals underwent cortical or thalamic injections of horseradish peroxidase and both antegrade and retrograde thalamic and cortical labeling have been analyzed. Ethanol-induced changes of thalamo-cortical circuits are prevented by concurrent administration of acetyl- l-carnitine.
Alterations of the thalamo-cortical system in rats prenatally exposed to ethanol are prevented by concurrent administration of acetyl-l-carnitine / SANTARELLI M; GRANATO A; SBRICCOLI A; GOBBI G; JANIRI L; D. MINCIACCHI. - In: BRAIN RESEARCH. - ISSN 0006-8993. - STAMPA. - 698:(1995), pp. 241-247. [10.1016/0006-8993(95)00997-5]
Alterations of the thalamo-cortical system in rats prenatally exposed to ethanol are prevented by concurrent administration of acetyl-l-carnitine.
MINCIACCHI, DIEGO
1995
Abstract
We previously demonstrated that adult rats prenatally exposed to ethanol display permanent damages of thalamo-cortical connections [18,19,33]. Here the effect of simultaneous administration of ethanol and acetyl- l-carnitine has been investigated. Adult animals underwent cortical or thalamic injections of horseradish peroxidase and both antegrade and retrograde thalamic and cortical labeling have been analyzed. Ethanol-induced changes of thalamo-cortical circuits are prevented by concurrent administration of acetyl- l-carnitine.
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