Diarylalkynes are readily transformed in 3-chlorobenzo[b]thiophenes in a two-step electrophilic addition-cyclization procedure that runs highly efficiently in solution or in the solid phase. The heteroaromatic carbon-chlorine bond participates in palladium-catalyzed Suzuki–Miyaura or Buchwald–Hartwig cross-couplings to give, in a single step, 2,3-disubstituted derivatives of pharmacological relevance
2,3-Disubstituted Benzo[b]thiophenes from Diaryl Alkynes via Electrophilic Addition-Cyclization and Palladium Catalyzed Cross-Coupling / G. Lamanna; S. Menichetti. - In: ADVANCED SYNTHESIS & CATALYSIS. - ISSN 1615-4150. - STAMPA. - 349:(2007), pp. 2188-2194. [10.1002/adsc.200700172]
2,3-Disubstituted Benzo[b]thiophenes from Diaryl Alkynes via Electrophilic Addition-Cyclization and Palladium Catalyzed Cross-Coupling
MENICHETTI, STEFANO
2007
Abstract
Diarylalkynes are readily transformed in 3-chlorobenzo[b]thiophenes in a two-step electrophilic addition-cyclization procedure that runs highly efficiently in solution or in the solid phase. The heteroaromatic carbon-chlorine bond participates in palladium-catalyzed Suzuki–Miyaura or Buchwald–Hartwig cross-couplings to give, in a single step, 2,3-disubstituted derivatives of pharmacological relevance
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