An original way to manage both stereochemistry and conformational constraints in ligand candidates for bioassays is presented with reference to a group of model N,N0-tetrasubstituted o-phthalamides and thioamides. The study shows that a scale of thermal flexibility in solution can be envisaged, the divisions of which are represented by compounds sharing quite similar geometrical features. NMR spectroscopy and powder X-ray analysis were used for the physical chemical investigation. An attempt to exploit the conformational instability of a model thioamide in the medium of a bioassay was also performed

A Way to Manage the Thermal Flexibility of Ligand Candidates for Bioassays / M. Altamura; G. Balacco; F. Cuda; A. Guidi; S. Meini; S. Menichetti; C. Nativi; F. Pasqui. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 62:(2006), pp. 6754-6761. [10.1016/j.tet.2006.05.011]

A Way to Manage the Thermal Flexibility of Ligand Candidates for Bioassays

MENICHETTI, STEFANO;NATIVI, CRISTINA;
2006

Abstract

An original way to manage both stereochemistry and conformational constraints in ligand candidates for bioassays is presented with reference to a group of model N,N0-tetrasubstituted o-phthalamides and thioamides. The study shows that a scale of thermal flexibility in solution can be envisaged, the divisions of which are represented by compounds sharing quite similar geometrical features. NMR spectroscopy and powder X-ray analysis were used for the physical chemical investigation. An attempt to exploit the conformational instability of a model thioamide in the medium of a bioassay was also performed
2006
62
6754
6761
M. Altamura; G. Balacco; F. Cuda; A. Guidi; S. Meini; S. Menichetti; C. Nativi; F. Pasqui
File in questo prodotto:
File Dimensione Formato  
2006_Tetra_06_6754.pdf

Accesso chiuso

Descrizione: Articolo principale
Tipologia: Pdf editoriale (Version of record)
Licenza: Tutti i diritti riservati
Dimensione 348.54 kB
Formato Adobe PDF
348.54 kB Adobe PDF   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/253914
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 3
social impact