In this study, we investigated the in vitro proliferative response of peripheral blood T lymphocytes from MS patients and controls to MBP and MOG either in the absence or in the presence of the conditioning factor IL-7. In the absence of IL-7, T-cell reactivity to MOG and MBP was similar in MS patients and controls even if an increased MBP response was found in a subgroup of patients with active disease. In the presence of IL-7, increased T-cell reactivity to MBP was observed in MS patients suggesting that their MBP-specific T cells are in a different functional state.
IL-7-enhanced T-cell response to myelin proteins in multiple sclerosis. J. Neuroimmunol / TRAGGIAI E; BIAGIOLI T; ROSATI E; BALLERINI C; MAZZANTI B; BEN NUN A; MASSACESI L; VERGELLI M;. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - ELETTRONICO. - 121:(2001), pp. 111-119. [10.1016/S0165-5728(01)00433-7]
IL-7-enhanced T-cell response to myelin proteins in multiple sclerosis. J. Neuroimmunol.
BIAGIOLI, TIZIANA;ROSATI, ELEONORA;BALLERINI, CLARA;MAZZANTI, BENEDETTA;MASSACESI, LUCA;VERGELLI, MARCO
2001
Abstract
In this study, we investigated the in vitro proliferative response of peripheral blood T lymphocytes from MS patients and controls to MBP and MOG either in the absence or in the presence of the conditioning factor IL-7. In the absence of IL-7, T-cell reactivity to MOG and MBP was similar in MS patients and controls even if an increased MBP response was found in a subgroup of patients with active disease. In the presence of IL-7, increased T-cell reactivity to MBP was observed in MS patients suggesting that their MBP-specific T cells are in a different functional state.
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