Subsequent to a genomic linkage study on Sardinian and Continental Italian families, we considered the possibility that some of the tested microsatellite markers showed association to MS. Markers selected on the basis of the data obtained in the original set of 70 multiplex families were tested for MS association in an additional set of 154 simplex families. A limited set of markers were further tested on an additional set of 100 simplex families. The results indicate the presence of a putative MS gene in 19q13.13.
An attempt of identifying MS-associated loci as a follow-up of a genomic linkage study in the Italian population / D'Alfonso S; Nisticò L; Bocchio D; Bomprezzi R; Marrosu MG; Murru MR; Lai M; Massacesi L; Ballerini C; Repice A; Salvetti M; Montesperelli C; Ristori G; Trojano M; Liguori M; Gambi D; Quattrone A; Tosi R; Momigliano-Richiardi P.. - In: JOURNAL OF NEUROVIROLOGY. - ISSN 1355-0284. - ELETTRONICO. - 6 (S 2):(2000), pp. 18-22.
An attempt of identifying MS-associated loci as a follow-up of a genomic linkage study in the Italian population.
MASSACESI, LUCA;BALLERINI, CLARA;
2000
Abstract
Subsequent to a genomic linkage study on Sardinian and Continental Italian families, we considered the possibility that some of the tested microsatellite markers showed association to MS. Markers selected on the basis of the data obtained in the original set of 70 multiplex families were tested for MS association in an additional set of 154 simplex families. A limited set of markers were further tested on an additional set of 100 simplex families. The results indicate the presence of a putative MS gene in 19q13.13.
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