Visual-sensory dysfunctions and semantic processing impairments are widely reported in Parkinson’s disease (PD) research. The present study investigated the category-specific deficit in object recognition as a function of both the semantic category and spatial frequency content of stimuli. In the first experiment, the role of dopamine in object-recognition processing was assessed by comparing PD drug na¨ıve (PD-DN), PD receiving levodopa treatment (PD-LD), and control subjects. Experiment 2 consisted of a retest session for PD drug na¨ıve subjects after a period of pharmacological treatment. All participants completed an identification task which displayed animals and tools at nine levels of filtering. Each object was revealed in a sequence of frames whereby the object was presented at increasingly less-filtered images up to a complete version of the image. Results indicate an impaired identification pattern for PD-DN subjects solely for animal category stimuli. This differential pharmacological therapy effect was also confirmed at retest (experiment 2). Thus, our data suggest that dopaminergic loss has a specific role in category-specific impairment. Two possible hypotheses are discussed that may account for the defective recognition of semantically different objects in PD.

Recognition of category-related visual stimuli in Parkinson's disease: before and after pharmacological treatment / S. RIGHI; M.P. VIGGIANO; M. PAGANINI; S. RAMAT; P. MARINI. - In: NEUROPSYCHOLOGIA. - ISSN 0028-3932. - STAMPA. - 45:(2007), pp. 2931-2941.

Recognition of category-related visual stimuli in Parkinson's disease: before and after pharmacological treatment.

RIGHI, STEFANIA;VIGGIANO, MARIA PIA;PAGANINI, MARCO;RAMAT, SILVIA;MARINI, PAOLO
2007

Abstract

Visual-sensory dysfunctions and semantic processing impairments are widely reported in Parkinson’s disease (PD) research. The present study investigated the category-specific deficit in object recognition as a function of both the semantic category and spatial frequency content of stimuli. In the first experiment, the role of dopamine in object-recognition processing was assessed by comparing PD drug na¨ıve (PD-DN), PD receiving levodopa treatment (PD-LD), and control subjects. Experiment 2 consisted of a retest session for PD drug na¨ıve subjects after a period of pharmacological treatment. All participants completed an identification task which displayed animals and tools at nine levels of filtering. Each object was revealed in a sequence of frames whereby the object was presented at increasingly less-filtered images up to a complete version of the image. Results indicate an impaired identification pattern for PD-DN subjects solely for animal category stimuli. This differential pharmacological therapy effect was also confirmed at retest (experiment 2). Thus, our data suggest that dopaminergic loss has a specific role in category-specific impairment. Two possible hypotheses are discussed that may account for the defective recognition of semantically different objects in PD.
2007
45
2931
2941
S. RIGHI; M.P. VIGGIANO; M. PAGANINI; S. RAMAT; P. MARINI
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/255720
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