Background: Protein Z, a vitamin K-dependent glycoprotein, serves as a cofactor for the inhibition of activated coagulation factor X. During recent years, a role for low levels of protein Z in prothrombotic disorders such as ischemic stroke and acute coronary syndromes (ACS) has been reported. The aims of this study were to test changes in protein Z and their association with outcome at 1-year follow-up in 193 (150 male, 43 female) patients with ACS. Results: Protein Z plasma levels were significantly lower (p < 0.0001) after 1 year [1600 (28-3736) ng/mL] compared to the baseline [1695 (294-4068) ng/mL]. Regression analysis showed a significant association between baseline protein Z below the 5th percentile of our control group and subsequent adverse cardiac events at follow-up (odds ratio 3.3; 95% CI 1.04-10.7; p=0.04). Moreover, Cox regression analysis showed that low protein Z levels at admission were significant predictors of major adverse cardiac events (cardiac death, non-fatal recurrent myocardial infarction, and need for target lesion revascularization) after 1 year (hazard risk 2.5; 95% CI 1.02-6.5, p=0.04). Conclusions: Our results show that in patients with ACS: 1) protein Z decreases moving from the acute to the convalescent phase; and 2) low levels of baseline protein Z are significantly associated with adverse outcome at 1-year follow-up.
Protein Z levels and prognosis in patients with acute coronary syndromes / F. SOFI; F. CESARI; R. MARCUCCI; C. FATINI; AM. GORI; C. GIGLIOLI; S. VALENTE; S. FEDI; R. ABBATE; GF. GENSINI. - In: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. - ISSN 1434-6621. - STAMPA. - 44:(2006), pp. 1098-1102. [10.1515/CCLM.2006.206]
Protein Z levels and prognosis in patients with acute coronary syndromes
SOFI, FRANCESCO;CESARI, FRANCESCA;MARCUCCI, ROSSELLA;FATINI, CINZIA;GORI, ANNA MARIA;FEDI, SANDRA;ABBATE, ROSANNA;GENSINI, GIAN FRANCO
2006
Abstract
Background: Protein Z, a vitamin K-dependent glycoprotein, serves as a cofactor for the inhibition of activated coagulation factor X. During recent years, a role for low levels of protein Z in prothrombotic disorders such as ischemic stroke and acute coronary syndromes (ACS) has been reported. The aims of this study were to test changes in protein Z and their association with outcome at 1-year follow-up in 193 (150 male, 43 female) patients with ACS. Results: Protein Z plasma levels were significantly lower (p < 0.0001) after 1 year [1600 (28-3736) ng/mL] compared to the baseline [1695 (294-4068) ng/mL]. Regression analysis showed a significant association between baseline protein Z below the 5th percentile of our control group and subsequent adverse cardiac events at follow-up (odds ratio 3.3; 95% CI 1.04-10.7; p=0.04). Moreover, Cox regression analysis showed that low protein Z levels at admission were significant predictors of major adverse cardiac events (cardiac death, non-fatal recurrent myocardial infarction, and need for target lesion revascularization) after 1 year (hazard risk 2.5; 95% CI 1.02-6.5, p=0.04). Conclusions: Our results show that in patients with ACS: 1) protein Z decreases moving from the acute to the convalescent phase; and 2) low levels of baseline protein Z are significantly associated with adverse outcome at 1-year follow-up.File | Dimensione | Formato | |
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