Conflicting findings regarding the association between protein Z and atherosclerotic disease have been reported. The aim of this case-control study was to evaluate the role of protein Z in a peripheral localization of atherosclerosis. We studied protein Z levels in 120 patients [102 M, 18 F; median age: 75 years] admitted to the Unit of Vascular Surgery of the University of Florence with a clinical manifestation of peripheral arterial disease (PAD), and in 360 healthy subjects selected to be comparable to the patients group in terms of age and gender. Protein Z levels were found to be significantly (p < 0.05) lower in PAD patients [1,594 (89-3,635) ng/mL] compared to the healthy control group [1,728 (300-3,736) ng/mL]. A logistic regression analysis showed, at univariate analysis, a significantly increased risk of PAD in patients with low levels of protein Z (<5th percentile of our control group: < 601 ng/mL) (OR: 5.72, 95%CI 3.07-10.66; p < 0.0001). After adjustment for age, gender and traditional cardiovascular risk factors the association was confirmed (OR: 5.83, 95%CI 2.83-12.01; p < 0.0001). Moreover, a significant association between low protein Z levels and clinical severity of the disease, evaluated through Fontaine’s stages, was reported after adjustment for age, gender, and traditional cardiovascular risk factors (general linear model, p for trend: 0.03). In conclusion, our data shows an association between low protein Z levels and the occurrence of PAD. These findings provide evidence for the role of protein Z in the pathogenesis of the atherosclerotic disease.

Low protein Z levels in patients with peripheral arterial disease / F. SOFI; F. CESARI; G. PRATESI; R. PULLI; C. PRATESI; G.F. GENSINI; R. ABBATE; S. FEDI; A.P: CELLAI. - In: THROMBOSIS AND HAEMOSTASIS. - ISSN 0340-6245. - STAMPA. - 98:(2007), pp. 1114-1117. [10.1160/TH07-04-0300]

Low protein Z levels in patients with peripheral arterial disease

F. SOFI;R. PULLI;C. PRATESI;G. F. GENSINI;R. ABBATE;S. FEDI;
2007

Abstract

Conflicting findings regarding the association between protein Z and atherosclerotic disease have been reported. The aim of this case-control study was to evaluate the role of protein Z in a peripheral localization of atherosclerosis. We studied protein Z levels in 120 patients [102 M, 18 F; median age: 75 years] admitted to the Unit of Vascular Surgery of the University of Florence with a clinical manifestation of peripheral arterial disease (PAD), and in 360 healthy subjects selected to be comparable to the patients group in terms of age and gender. Protein Z levels were found to be significantly (p < 0.05) lower in PAD patients [1,594 (89-3,635) ng/mL] compared to the healthy control group [1,728 (300-3,736) ng/mL]. A logistic regression analysis showed, at univariate analysis, a significantly increased risk of PAD in patients with low levels of protein Z (<5th percentile of our control group: < 601 ng/mL) (OR: 5.72, 95%CI 3.07-10.66; p < 0.0001). After adjustment for age, gender and traditional cardiovascular risk factors the association was confirmed (OR: 5.83, 95%CI 2.83-12.01; p < 0.0001). Moreover, a significant association between low protein Z levels and clinical severity of the disease, evaluated through Fontaine’s stages, was reported after adjustment for age, gender, and traditional cardiovascular risk factors (general linear model, p for trend: 0.03). In conclusion, our data shows an association between low protein Z levels and the occurrence of PAD. These findings provide evidence for the role of protein Z in the pathogenesis of the atherosclerotic disease.
2007
98
1114
1117
F. SOFI; F. CESARI; G. PRATESI; R. PULLI; C. PRATESI; G.F. GENSINI; R. ABBATE; S. FEDI; A.P: CELLAI
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/256128
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