The synthesis of two new bicyclic nucleoside analogues is reported. These compounds are iso-homonucleoside and are synthesised through a 1,3-dipolar cycloaddition of an enantiopure cyclic nitrone to protected allyl acohol and subsequent introduction of thymine by a Mitsunobu reaction.
Stereoselective synthesis of new bicyclic N,O-iso-homonucleoside analogues / B. Richichi; S. Cicchi; U. Chiacchio; G. Romeo; A. Brandi. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 59:(2003), pp. 5231-5240. [10.1016/S0040-4020(03)00772-5]
Stereoselective synthesis of new bicyclic N,O-iso-homonucleoside analogues
RICHICHI, BARBARA;CICCHI, STEFANO;BRANDI, ALBERTO
2003
Abstract
The synthesis of two new bicyclic nucleoside analogues is reported. These compounds are iso-homonucleoside and are synthesised through a 1,3-dipolar cycloaddition of an enantiopure cyclic nitrone to protected allyl acohol and subsequent introduction of thymine by a Mitsunobu reaction.
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