We extracted, purified and characterized 8 sesquiterpene fractions from Commyphora molmol. In particular, we focused our attention on a mixture of furanodiene-6-one and methoxyfuranoguaia-9-ene-8-one, which showed antibacterial and antifungal activity against standard pathogenic strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans, with minimum inhibitory concentrations ranging from 0.18 to 2.8 micrograms/ml. These compounds also had local anaesthetic activity, blocking the inward sodium current of excitable mammalian membranes.
Local anaesthetic, antibacterial and antifungal properties of sesquiterpenes from myrrh / P. DOLARA; B. CORTE; C. GHELARDINI; A.M. PUGLIESE; E. CERBAI; S. MENICHETTI; A. LO NOSTRO. - In: PLANTA MEDICA. - ISSN 0032-0943. - STAMPA. - 66:(2000), pp. 356-358. [10.1055/s-2000-8532]
Local anaesthetic, antibacterial and antifungal properties of sesquiterpenes from myrrh.
DOLARA, PIERO;GHELARDINI, CARLA;PUGLIESE, ANNA MARIA;CERBAI, ELISABETTA;MENICHETTI, STEFANO;LO NOSTRO, ANTONELLA
2000
Abstract
We extracted, purified and characterized 8 sesquiterpene fractions from Commyphora molmol. In particular, we focused our attention on a mixture of furanodiene-6-one and methoxyfuranoguaia-9-ene-8-one, which showed antibacterial and antifungal activity against standard pathogenic strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans, with minimum inhibitory concentrations ranging from 0.18 to 2.8 micrograms/ml. These compounds also had local anaesthetic activity, blocking the inward sodium current of excitable mammalian membranes.
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