Host specific T-cell response is critical for the outcome of Helicobacter pylori infection. In genetically susceptible individuals, H. pylori can activate gastric CD4+ Th1 cells that recognize cross-reactive epitopes shared by H. pylori proteins and self H+, K+-ATPase, leading to gastric autoimmunity via molecular mimicry.
Helicobacter pylori and gastric autoimmunity / MM. D'ELIOS MM; MP. BERGMAN; A. AMEDEI; BJ. APPELMELK; G. DEL PRETE. - In: MICROBES AND INFECTION. - ISSN 1286-4579. - STAMPA. - 6:(2004), pp. 1395-1401. [10.1016/j.micinf.2004.10.001]
Helicobacter pylori and gastric autoimmunity.
D'ELIOS, MARIO MILCO;AMEDEI, AMEDEO;DEL PRETE, GIANFRANCO
2004
Abstract
Host specific T-cell response is critical for the outcome of Helicobacter pylori infection. In genetically susceptible individuals, H. pylori can activate gastric CD4+ Th1 cells that recognize cross-reactive epitopes shared by H. pylori proteins and self H+, K+-ATPase, leading to gastric autoimmunity via molecular mimicry.
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