Enantiomerically Pure Dendrimers Based on a trans-3,4-Dihydroxypyrrolidine

The synthesis of the first and second generation of enantiopure dendrimers based on a chiral trans-3,4- dihydroxypyrrolidine is reported. Benzenepolycarboxylic acids were used as central nucleus to afford linear and radial growth, and terephthalic acid was used as spacer between the pyrrolidine nuclei. The analysis of the chiroptical properties ([]D, circular dichroism) of these new dendrimers suggests that those with radial growth present a self organisation of chiral units.