Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-aminopiperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9, active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer’s disease.
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs / D. MANETTI; E. MARTINI; C. GHELARDINI; S. DEI; N. GALEOTTI; L. GUANDALINI; M. ROMANELLI; S. SCAPECCHI; E. TEODORI; A. BARTOLINI; F. GUALTIERI. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 13:(2003), pp. 2303-2306. [10.1016/S0960-894X(03)00437-2]
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs
MANETTI, DINA;MARTINI, ELISABETTA;GHELARDINI, CARLA;DEI, SILVIA;GALEOTTI, NICOLETTA;GUANDALINI, LUCA;ROMANELLI, MARIA NOVELLA;SCAPECCHI, SERENA;TEODORI, ELISABETTA;BARTOLINI, ALESSANDRO;GUALTIERI, FULVIO
2003
Abstract
Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-aminopiperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9, active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer’s disease.
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79.Manetti 2003
accesso aperto
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Versione finale referata (Postprint, Accepted manuscript)
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Open Access
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179.82 kB
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