The alterations in the mucociliary unit in the course of chronic inflammation of the upper respiratory tract correspond to morphologic anomalies of the respiratory epithelium and induce cuboidal and squamous metaplasia. While the squamous pattern is most probably irreversible, it is still not clear whether it is possible to restore ciliogenesis in cuboidal metaplasia. In the present study, the action of different inductors of differentiation was evaluated in vitro in isolated cells and explants from human nasal metaplastic epithelium. Polar/apolar compounds induced secretory activity, whereas retinoic acid was able to induce ciliogenesis in some cases. Therefore, the cuboidal metaplastic condition appears to be reversible, and two distinct pathways of differentiation, secretory and ciliogenetic, are identifiable.

In vitro effects of some differentiation inductors in metaplastic epithelium of the human nasal cavity / M. Gulisano; S. Pacini; M. Ruggiero; A. Pacini; A. Del Rio; P. Pacini;. - In: CELL AND TISSUE RESEARCH. - ISSN 0302-766X. - STAMPA. - 285:(1996), pp. 119-125. [10.1007/s004410050627]

In vitro effects of some differentiation inductors in metaplastic epithelium of the human nasal cavity

GULISANO, MASSIMO;PACINI, STEFANIA;RUGGIERO, MARCO;PACINI, ALESSANDRA;
1996

Abstract

The alterations in the mucociliary unit in the course of chronic inflammation of the upper respiratory tract correspond to morphologic anomalies of the respiratory epithelium and induce cuboidal and squamous metaplasia. While the squamous pattern is most probably irreversible, it is still not clear whether it is possible to restore ciliogenesis in cuboidal metaplasia. In the present study, the action of different inductors of differentiation was evaluated in vitro in isolated cells and explants from human nasal metaplastic epithelium. Polar/apolar compounds induced secretory activity, whereas retinoic acid was able to induce ciliogenesis in some cases. Therefore, the cuboidal metaplastic condition appears to be reversible, and two distinct pathways of differentiation, secretory and ciliogenetic, are identifiable.
1996
285
119
125
M. Gulisano; S. Pacini; M. Ruggiero; A. Pacini; A. Del Rio; P. Pacini;
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/310369
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