As a continuation of previous research on anticholinergic drugs derived from 2,2-diphenyl-2-ethylthioacetic acid, several compounds were synthesized and theirantimuscarinic activity on M1-M4 receptor subtypes was evaluated by functional tests and binding experiments. One of the compounds obtained showed unexpected agonistic activity in functional experiments on M2 receptors.
Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists / Scapecchi, Serena; Marucci, G.; Matucci, Rosanna; Angeli, P.; Bellucci, Cristina; Buccioni, M.; Dei, Silvia; Gualtieri, Fulvio; Manetti, Dina; Romanelli, MARIA NOVELLA; Teodori, Elisabetta. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - STAMPA. - 9:(2001), pp. 1165-1174.
Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists.
SCAPECCHI, SERENA;MATUCCI, ROSANNA;BELLUCCI, CRISTINA;DEI, SILVIA;GUALTIERI, FULVIO;MANETTI, DINA;ROMANELLI, MARIA NOVELLA;TEODORI, ELISABETTA
2001
Abstract
As a continuation of previous research on anticholinergic drugs derived from 2,2-diphenyl-2-ethylthioacetic acid, several compounds were synthesized and theirantimuscarinic activity on M1-M4 receptor subtypes was evaluated by functional tests and binding experiments. One of the compounds obtained showed unexpected agonistic activity in functional experiments on M2 receptors.
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