Interleukin-4 (IL-4) and IL-4delta2 mRNA gastric expression was evaluated in healthy subjects and patients who did not have ulcers but were infected with Helicobacter pylori with or without the cag pathogenicity island (cag PAI). IL-4 mRNA was physiologically expressed by gastric epithelium and negatively influenced by H. pylori. Also, nonepithelial cells in the lamina propria of H. pylori-infected patients expressed IL-4 mRNA, whereas IL-4delta2 mRNA was found only in cag PAI-negative patients. Thus, gastric IL-4 takes part in the local immune response to H. pylori.

Helicobacter pylori cag pathogenicity island is associated with reduced expression of IL-4 mRNA and modulation of IL-4d2 mRNA isoform in human gastric mucosa / ORSINI B; OTTANELLI B; AMEDEI A; SURRENTI E; CAPANNI M; DEL PRETE G; AMOROSI A; S. MILANI; D'ELIOS M.M.; SURRENTI C.. - In: INFECTION AND IMMUNITY. - ISSN 0019-9567. - STAMPA. - 71:(2003), pp. 6664-6667.

Helicobacter pylori cag pathogenicity island is associated with reduced expression of IL-4 mRNA and modulation of IL-4d2 mRNA isoform in human gastric mucosa

AMEDEI, AMEDEO;SURRENTI, CALOGERO;DEL PRETE, GIANFRANCO;MILANI, STEFANO;D'ELIOS, MARIO MILCO;
2003

Abstract

Interleukin-4 (IL-4) and IL-4delta2 mRNA gastric expression was evaluated in healthy subjects and patients who did not have ulcers but were infected with Helicobacter pylori with or without the cag pathogenicity island (cag PAI). IL-4 mRNA was physiologically expressed by gastric epithelium and negatively influenced by H. pylori. Also, nonepithelial cells in the lamina propria of H. pylori-infected patients expressed IL-4 mRNA, whereas IL-4delta2 mRNA was found only in cag PAI-negative patients. Thus, gastric IL-4 takes part in the local immune response to H. pylori.
2003
71
6664
6667
ORSINI B; OTTANELLI B; AMEDEI A; SURRENTI E; CAPANNI M; DEL PRETE G; AMOROSI A; S. MILANI; D'ELIOS M.M.; SURRENTI C.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/311086
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