Abstract We analyzed at clonal level the functional profile of circulating or skin-infiltrating T lymphocytes from two individuals infected with the human immunodeficiency virus type 1 (HIV-1), suffering from a Job's-like syndrome (eczematous dermatitis, recurrent skin and sinopulmonary infections, and hypergammaglobulinemia E) and showing virtually no circulating CD4+ T cells. Most of the CD3+ T cell clones generated from both patients were CD4- CD8+ TCR alpha beta +. The others were CD4- CD8- TCR alpha beta + which exhibited reduced mRNA expression for the CD8 molecule or no mRNA expression for either CD4 or CD8 molecules. The great majority of both CD4- CD8+ and CD4- CD8- did not produce interferon (IFN) gamma and exhibited reduced cytolytic activity. Rather, most of them produced large amounts of both interleukin (IL) 4 and IL-5 and provided B cell helper function for IgE synthesis. These data suggest that a switch of cytolytic CD8+ T cells showing a Th1-like cytokine secretion profile to cells that make Th2-type cytokines, exhibit reduced cytolytic potential, and provide B cell helper function can occur in the course of HIV-1 infection. These cells may contribute to the reduced defense against viral infections and intracellular parasites and account for the elevated IgE serum levels, eosinophilia, and the allergic-like clinical manifestations seen in a proportion of HIV-1-infected individuals.

Th2-like CD8+ cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type 1 infection / MAGGI E.; GIUDIZI MG.; BIAGIOTTI R.; F. ANNUNZIATO; MANETTI R.; PICCINNI MP.; PARRONCHI P.; SAMPOGNARO S.; GIANNARINI L.; ZUCCATI G.; ROMAGNANI S.. - In: JOURNAL OF EXPERIMENTAL MEDICINE. - ISSN 0022-1007. - STAMPA. - 180:(1994), pp. 489-495.

Th2-like CD8+ cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type 1 infection.

MAGGI, ENRICO;GIUDIZI, MARIA GRAZIA;BIAGIOTTI, ROBERTA;ANNUNZIATO, FRANCESCO;PICCINNI, MARIE-PIERRE;PARRONCHI, PAOLA;SAMPOGNARO, SALVATORE;ZUCCATI, GIULIANO;ROMAGNANI, SERGIO
1994

Abstract

Abstract We analyzed at clonal level the functional profile of circulating or skin-infiltrating T lymphocytes from two individuals infected with the human immunodeficiency virus type 1 (HIV-1), suffering from a Job's-like syndrome (eczematous dermatitis, recurrent skin and sinopulmonary infections, and hypergammaglobulinemia E) and showing virtually no circulating CD4+ T cells. Most of the CD3+ T cell clones generated from both patients were CD4- CD8+ TCR alpha beta +. The others were CD4- CD8- TCR alpha beta + which exhibited reduced mRNA expression for the CD8 molecule or no mRNA expression for either CD4 or CD8 molecules. The great majority of both CD4- CD8+ and CD4- CD8- did not produce interferon (IFN) gamma and exhibited reduced cytolytic activity. Rather, most of them produced large amounts of both interleukin (IL) 4 and IL-5 and provided B cell helper function for IgE synthesis. These data suggest that a switch of cytolytic CD8+ T cells showing a Th1-like cytokine secretion profile to cells that make Th2-type cytokines, exhibit reduced cytolytic potential, and provide B cell helper function can occur in the course of HIV-1 infection. These cells may contribute to the reduced defense against viral infections and intracellular parasites and account for the elevated IgE serum levels, eosinophilia, and the allergic-like clinical manifestations seen in a proportion of HIV-1-infected individuals.
1994
180
489
495
MAGGI E.; GIUDIZI MG.; BIAGIOTTI R.; F. ANNUNZIATO; MANETTI R.; PICCINNI MP.; PARRONCHI P.; SAMPOGNARO S.; GIANNARINI L.; ZUCCATI G.; ROMAGNANI S....espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/311259
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