We investigated in rats the effect N -nitro-L-arginine methyl ester (L-NAME) on retention of a passive avoidance response, and cortical ACh release monitored using the microdialysis technique. Post-training administration of L-NAME impaired 24 h retention of a passive avoidance and decreased cortical ACh release. Both effects of L-NAME were reversed by L-Arg. These results suggest that nitric oxide is involved in retention of the passive avoidance response through the modulation of the forebrain cholinergic system.
NO synthesis inhibition decreases cortical ACh release and impairs retention of a conditioned response / KOPF S.R.; BENTON R.S.; KALFIN R.; GIOVANNINI M.G.; G. PEPEU. - In: BRAIN RESEARCH. - ISSN 0006-8993. - STAMPA. - 894:(2001), pp. 141-144. [10.1016/S0006-8993(00)03148-6]
NO synthesis inhibition decreases cortical ACh release and impairs retention of a conditioned response
GIOVANNINI, MARIA GRAZIA;PEPEU, GIANCARLO
2001
Abstract
We investigated in rats the effect N -nitro-L-arginine methyl ester (L-NAME) on retention of a passive avoidance response, and cortical ACh release monitored using the microdialysis technique. Post-training administration of L-NAME impaired 24 h retention of a passive avoidance and decreased cortical ACh release. Both effects of L-NAME were reversed by L-Arg. These results suggest that nitric oxide is involved in retention of the passive avoidance response through the modulation of the forebrain cholinergic system.File | Dimensione | Formato | |
---|---|---|---|
2001_BrainRes.pdf
Accesso chiuso
Tipologia:
Versione finale referata (Postprint, Accepted manuscript)
Licenza:
Tutti i diritti riservati
Dimensione
283.72 kB
Formato
Adobe PDF
|
283.72 kB | Adobe PDF | Richiedi una copia |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.