Pixantrone is an immunesuppressor similar to mitoxantrone but with lower cardiotoxicity. We evaluated the effect of pixantrone on B cells and lymphomononuclear cells in the course of acute EAE. Pixantrone reduced the number of B cells and suppressed myelin basic protein (MBP) specific IgG production. In vitro, pixantrone induced apoptosis of rat B lymphocytes in a way similar to mitoxantrone. In addition, pixantrone inhibited antigen specific and mitogen induced lymphomononuclear cell proliferation, as well as IFN-gamma production, during EAE. These findings suggest a similar mechanism of action for pixantrone and mitoxantrone on the effector function of lymphomonocyte B and T cells.
Effects of pixantrone on immune-cell function in the course of acute rat experimental allergic encephalomyelitis / MAZZANTI B, BIAGIOLI T, ALDINUCCI A, CAVALETTI G, CAVALLETTI E, OGGIONI N, FRIGO M, ROTA S, TAGLIABUE E, BALLERINI C, MASSACESI L, RICCIO P, LOLLI F. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - ELETTRONICO. - 168:(2005), pp. 111-117. [10.1016/j.jneuroim.2005.07.010]
Effects of pixantrone on immune-cell function in the course of acute rat experimental allergic encephalomyelitis.
MAZZANTI, BENEDETTA;BIAGIOLI, TIZIANA;ALDINUCCI, ALESSANDRA;BALLERINI, CLARA;MASSACESI, LUCA;LOLLI, FRANCESCO
2005
Abstract
Pixantrone is an immunesuppressor similar to mitoxantrone but with lower cardiotoxicity. We evaluated the effect of pixantrone on B cells and lymphomononuclear cells in the course of acute EAE. Pixantrone reduced the number of B cells and suppressed myelin basic protein (MBP) specific IgG production. In vitro, pixantrone induced apoptosis of rat B lymphocytes in a way similar to mitoxantrone. In addition, pixantrone inhibited antigen specific and mitogen induced lymphomononuclear cell proliferation, as well as IFN-gamma production, during EAE. These findings suggest a similar mechanism of action for pixantrone and mitoxantrone on the effector function of lymphomonocyte B and T cells.
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