IFN-gamma-inducible protein 10 (IP-10/CXCL10) is a chemokine involved in delayed-type hypersensitivity and attraction of monocytes and activated T lymphocytes at inflammatory foci, whereas pentraxin 3 (PTX3) is part of the innate immune response. In the Republic of Guinea, 220 newly diagnosed, HIV-negative, pulmonary tuberculosis (TB) patients were studied together with 220 healthy household controls and 220 community controls. CXCL10 and PTX3 blood levels were assessed by ELISA at diagnosis, after 2 months and at the end of treatment. In untreated patients, both CXCL10 and PTX3 levels were higher (P < 0.0001) than in controls, although household controls had higher (P < 0.0001) CXCL10 and PTX3 levels than community controls, but lower (P < 0.0001) than those of patients. At the end of treatment, 186 cured patients showed reduction (P < 0.0001) in both CXCL10 and PTX3 levels. In 34 patients with treatment failure, both CXCL10 and PTX3 levels increased further. In five previously healthy households who developed TB during the follow-up and in two patients who relapsed after treatment, a remarkable increase in both CXCL10 and PTX3 plasma levels was observed. Active TB is associated with increased CXCL10 and PTX3 levels in the plasma. Although not specific for TB, measurement of these proteins may help the monitoring of disease activity and efficacy of therapy.

IFN-g-inducible protein (IP-10/CXCL)10 and pentraxin (PTX)3 plasma levels are tools for monitoring inflammation and disease activity in M. tuberculosis infection / AZZURRI A.; SOW O.Y.; A. AMEDEI; BAH B.; DIALLO S.; PERI G.; BENAGIANO M.; D'ELIOS M.M.; MANTOVANI A.; DEL PRETE G.. - In: MICROBES AND INFECTION. - ISSN 1286-4579. - STAMPA. - 7:(2005), pp. 1-8. [10.1016/j.micinf.2004.09.004]

IFN-g-inducible protein (IP-10/CXCL)10 and pentraxin (PTX)3 plasma levels are tools for monitoring inflammation and disease activity in M. tuberculosis infection.

AZZURRI, ANNALISA;AMEDEI, AMEDEO;BENAGIANO, MARISA;D'ELIOS, MARIO MILCO;DEL PRETE, GIANFRANCO
2005

Abstract

IFN-gamma-inducible protein 10 (IP-10/CXCL10) is a chemokine involved in delayed-type hypersensitivity and attraction of monocytes and activated T lymphocytes at inflammatory foci, whereas pentraxin 3 (PTX3) is part of the innate immune response. In the Republic of Guinea, 220 newly diagnosed, HIV-negative, pulmonary tuberculosis (TB) patients were studied together with 220 healthy household controls and 220 community controls. CXCL10 and PTX3 blood levels were assessed by ELISA at diagnosis, after 2 months and at the end of treatment. In untreated patients, both CXCL10 and PTX3 levels were higher (P < 0.0001) than in controls, although household controls had higher (P < 0.0001) CXCL10 and PTX3 levels than community controls, but lower (P < 0.0001) than those of patients. At the end of treatment, 186 cured patients showed reduction (P < 0.0001) in both CXCL10 and PTX3 levels. In 34 patients with treatment failure, both CXCL10 and PTX3 levels increased further. In five previously healthy households who developed TB during the follow-up and in two patients who relapsed after treatment, a remarkable increase in both CXCL10 and PTX3 plasma levels was observed. Active TB is associated with increased CXCL10 and PTX3 levels in the plasma. Although not specific for TB, measurement of these proteins may help the monitoring of disease activity and efficacy of therapy.
2005
7
1
8
AZZURRI A.; SOW O.Y.; A. AMEDEI; BAH B.; DIALLO S.; PERI G.; BENAGIANO M.; D'ELIOS M.M.; MANTOVANI A.; DEL PRETE G.
File in questo prodotto:
File Dimensione Formato  
IFN-γ-inducible protein 10 and pentraxin 3 plasma levels are tools for monitoring inflammation and disease activity in Mycobacterium tuberculosis infection.pdf

Accesso chiuso

Tipologia: Pdf editoriale (Version of record)
Licenza: Tutti i diritti riservati
Dimensione 237.73 kB
Formato Adobe PDF
237.73 kB Adobe PDF   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/313130
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 222
  • ???jsp.display-item.citation.isi??? 202
social impact