The synthesis of a new acridine derivativeb (D) is presented. The characteristics of the compound and its ZnII complex were analysed by means of NMR spectroscopy, potentiometric, spectrophotometric and spectrofluorimetric techniques. The equilibria and kinetics of the binding process of D and [ZnD] to calf thymus DNA have been investigated. Molecular-modelling studies support the intercalative process and evidence the influence of NH+···O interactions between the protonated acridine nitrogen atom and the oxygen atoms of the polyanion
DNA binding by a new metallointercalator that contains a proflavine group bearing a hanging chelating unit / C. Bazzicalupi; A. Bencini; A. Bianchi; T. Biver; A. Boggioni; S. Bonacchi; A. Danesi; C. Giorgi; P. Gratteri; A. Marcal Ingraín; F. Secco; C. Sissi; B. Valtancoli; M. Venturini. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - STAMPA. - 14:(2008), pp. 184-196. [10.1002/chem.200601855]
DNA binding by a new metallointercalator that contains a proflavine group bearing a hanging chelating unit.
BAZZICALUPI, CARLA;BENCINI, ANDREA;BIANCHI, ANTONIO;GIORGI, CLAUDIA;GRATTERI, PAOLA;VALTANCOLI, BARBARA;
2008
Abstract
The synthesis of a new acridine derivativeb (D) is presented. The characteristics of the compound and its ZnII complex were analysed by means of NMR spectroscopy, potentiometric, spectrophotometric and spectrofluorimetric techniques. The equilibria and kinetics of the binding process of D and [ZnD] to calf thymus DNA have been investigated. Molecular-modelling studies support the intercalative process and evidence the influence of NH+···O interactions between the protonated acridine nitrogen atom and the oxygen atoms of the polyanion
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