Abstract BACKGROUND: Although antidepressant drugs (ATD) are frequently prescribed to patients with Alzheimer's disease (AD), their effect on cognitive status has been only rarely assessed. METHODS: The impact of depressive symptoms and ATD on cognitive status was retrospectively assessed in 72 older AD outpatients with mild-to-moderate cognitive impairment, treated with cholinesterase inhibitors, over a 9-month follow-up. RESULTS: Compared to subjects without baseline depressive symptoms, those with symptoms who were continuously treated with ATD had less cognitive decline; those never treated, or not continuously treated despite baseline symptoms, had an intermediate trend. Such a protective action of ATD was, at least in part, independent of their action on depressive symptoms. CONCLUSION: These observations suggest that ATD may reduce cognitive decline in depressed older AD patients.

Is antidepressant treatment associated with reduced cognitive decline in Alzheimer's disease? / E. MOSSELLO; M. BONCINELLI; V. CALERI; MC. CAVALLINI; E. PALERMO; M. DI BARI; S. TILLI; E. SARCONE; D. SIMONI; CA. BIAGINI; G. MASOTTI; N. MARCHIONNI. - In: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS. - ISSN 1420-8008. - STAMPA. - 25:(2008), pp. 372-379.

Is antidepressant treatment associated with reduced cognitive decline in Alzheimer's disease?

MOSSELLO, ENRICO;BONCINELLI, MARTA;CALERI, VERONICA;CAVALLINI, MARIA CHIARA;DI BARI, MAURO;SIMONI, DAVID;MASOTTI, GIULIO;MARCHIONNI, NICCOLO'
2008

Abstract

Abstract BACKGROUND: Although antidepressant drugs (ATD) are frequently prescribed to patients with Alzheimer's disease (AD), their effect on cognitive status has been only rarely assessed. METHODS: The impact of depressive symptoms and ATD on cognitive status was retrospectively assessed in 72 older AD outpatients with mild-to-moderate cognitive impairment, treated with cholinesterase inhibitors, over a 9-month follow-up. RESULTS: Compared to subjects without baseline depressive symptoms, those with symptoms who were continuously treated with ATD had less cognitive decline; those never treated, or not continuously treated despite baseline symptoms, had an intermediate trend. Such a protective action of ATD was, at least in part, independent of their action on depressive symptoms. CONCLUSION: These observations suggest that ATD may reduce cognitive decline in depressed older AD patients.
2008
25
372
379
E. MOSSELLO; M. BONCINELLI; V. CALERI; MC. CAVALLINI; E. PALERMO; M. DI BARI; S. TILLI; E. SARCONE; D. SIMONI; CA. BIAGINI; G. MASOTTI; N. MARCHIONNI
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/315019
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