The results of a study aimed at improving the dissolution properties of naproxen via solid dispersion systems prepared by colyophilization with polyvinylpyrrolidone were reported. Drug-polymer interaction models both in aqueous solution and in the solid state were proposed.
Solubilization and interaction of naproxen with polyvinyl-pyrrolidone in aqueous solution and in the solid state / G.P. Bettinetti; P. Mura; A. Liguori; G. Bramanti; F.Giordano. - In: IL FARMACO. EDIZIONE PRATICA. - ISSN 0430-0912. - STAMPA. - 43:(1988), pp. 331-343.
Solubilization and interaction of naproxen with polyvinyl-pyrrolidone in aqueous solution and in the solid state
BETTINETTI, GIAMPIERO;MURA, PAOLA ANGELA;LIGUORI, ANTONELLA UGHETTA;BRAMANTI, GIAMPIERO;
1988
Abstract
The results of a study aimed at improving the dissolution properties of naproxen via solid dispersion systems prepared by colyophilization with polyvinylpyrrolidone were reported. Drug-polymer interaction models both in aqueous solution and in the solid state were proposed.
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