Pan coating techniques with insoluble polymers (Eudragit E30D and cellulose acetate phtalate) were examined for delaying the drug reease rate from hydroxypropyl-methylcellulose matrix tablets. Ketoprofen and sodium meclofenamate were used as model drugs. The in vitro release profiles form each formulation were studied by the USP basket method. Coating with Eudragit (mixed with 5% PEG 400) gave the best results; however, also cellulose acetate phtalate showed interesting unexpected results, being effective not only as gastro-resistent but also as delaying agent.
Pan-coating techniques for delaying drug release from hydroxypropyl methylcellulose matrix tablets / P. Mura; L. Fabbri. - STAMPA. - (1992), pp. 483-489. (Intervento presentato al convegno 6th International Conference on Pharmaceutical Technology tenutosi a Parigi nel 2-4 giugno 1992).
Pan-coating techniques for delaying drug release from hydroxypropyl methylcellulose matrix tablets
MURA, PAOLA ANGELA;
1992
Abstract
Pan coating techniques with insoluble polymers (Eudragit E30D and cellulose acetate phtalate) were examined for delaying the drug reease rate from hydroxypropyl-methylcellulose matrix tablets. Ketoprofen and sodium meclofenamate were used as model drugs. The in vitro release profiles form each formulation were studied by the USP basket method. Coating with Eudragit (mixed with 5% PEG 400) gave the best results; however, also cellulose acetate phtalate showed interesting unexpected results, being effective not only as gastro-resistent but also as delaying agent.
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