Severe myoclonic epilepsy in infancy (SMEI) is a rare, but severe disorder with seizures typically resistant to conventional antiepileptic drugs. The objective of the present study was to systematically review the literature on the available treatments for SMEI. Databases searched included Medline, Embase, and Cochrane. We used a fixed effect model to summarize the odds ratio of seizures rates and a logistic model to evaluate the influence of patient characteristics on treatment effect.
Severe myoclonic epilepsy in infancy: a systematic review and a meta-analysis of individual patient data / Kassaï B; Chiron C; Augier S; Cucherat M; Rey E; Gueyffier F; Guerrini R; Vincent J; Dulac O; Pons G.. - In: EPILEPSIA. - ISSN 0013-9580. - STAMPA. - 49 (2):(2008), pp. 343-348. [10.1111/j.1528-1167.2007.01423.x]
Severe myoclonic epilepsy in infancy: a systematic review and a meta-analysis of individual patient data.
GUERRINI, RENZO;
2008
Abstract
Severe myoclonic epilepsy in infancy (SMEI) is a rare, but severe disorder with seizures typically resistant to conventional antiepileptic drugs. The objective of the present study was to systematically review the literature on the available treatments for SMEI. Databases searched included Medline, Embase, and Cochrane. We used a fixed effect model to summarize the odds ratio of seizures rates and a logistic model to evaluate the influence of patient characteristics on treatment effect.
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