Mixed cryoglobulinemia (MC) is a systemic small-vessel vasculitis; B-cell expansion is the biological substrate of the disease. It can be regarded as benign lymphoproliferative condition that may evolve to frank lymphoma. HCV infection is the main causative factor of MC, as well as of other overlapping disorders, through multifactorial and multistep pathogenetic process. HCV-related B-cell proliferation represents an important model of virus-driven autoimmune/neoplastic disorder. The term HCV syndrome is referred to a wide spectrum of both hepatic and extrahepatic disorders. The present review analyzes the complex virological, clinico-pathological, and therapeutic implications of B-cell proliferation, with or without HCV infection, in MC patients.

B-cells and mixed cryoglobulinemia / C. Ferri; A. Antonelli; M. Mascia;M. Sebastiani; P. Fallahi; D. Ferrari; M. Giunti; S. Pileri; A.L. Zignego;. - In: AUTOIMMUNITY REVIEWS. - ISSN 1568-9972. - STAMPA. - 7(2)(2007), pp. 114-120.

B-cells and mixed cryoglobulinemia

ZIGNEGO, ANNA LINDA
2007

Abstract

Mixed cryoglobulinemia (MC) is a systemic small-vessel vasculitis; B-cell expansion is the biological substrate of the disease. It can be regarded as benign lymphoproliferative condition that may evolve to frank lymphoma. HCV infection is the main causative factor of MC, as well as of other overlapping disorders, through multifactorial and multistep pathogenetic process. HCV-related B-cell proliferation represents an important model of virus-driven autoimmune/neoplastic disorder. The term HCV syndrome is referred to a wide spectrum of both hepatic and extrahepatic disorders. The present review analyzes the complex virological, clinico-pathological, and therapeutic implications of B-cell proliferation, with or without HCV infection, in MC patients.
7(2)
114
120
C. Ferri; A. Antonelli; M. Mascia;M. Sebastiani; P. Fallahi; D. Ferrari; M. Giunti; S. Pileri; A.L. Zignego;
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2158/318301
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