Mixed cryoglobulinemia (MC) is a systemic small-vessel vasculitis; B-cell expansion is the biological substrate of the disease. It can be regarded as benign lymphoproliferative condition that may evolve to frank lymphoma. HCV infection is the main causative factor of MC, as well as of other overlapping disorders, through multifactorial and multistep pathogenetic process. HCV-related B-cell proliferation represents an important model of virus-driven autoimmune/neoplastic disorder. The term HCV syndrome is referred to a wide spectrum of both hepatic and extrahepatic disorders. The present review analyzes the complex virological, clinico-pathological, and therapeutic implications of B-cell proliferation, with or without HCV infection, in MC patients.

B-cells and mixed cryoglobulinemia / C. Ferri; A. Antonelli; M. Mascia;M. Sebastiani; P. Fallahi; D. Ferrari; M. Giunti; S. Pileri; A.L. Zignego;. - In: AUTOIMMUNITY REVIEWS. - ISSN 1568-9972. - STAMPA. - 7(2):(2007), pp. 114-120.

B-cells and mixed cryoglobulinemia

ZIGNEGO, ANNA LINDA
2007

Abstract

Mixed cryoglobulinemia (MC) is a systemic small-vessel vasculitis; B-cell expansion is the biological substrate of the disease. It can be regarded as benign lymphoproliferative condition that may evolve to frank lymphoma. HCV infection is the main causative factor of MC, as well as of other overlapping disorders, through multifactorial and multistep pathogenetic process. HCV-related B-cell proliferation represents an important model of virus-driven autoimmune/neoplastic disorder. The term HCV syndrome is referred to a wide spectrum of both hepatic and extrahepatic disorders. The present review analyzes the complex virological, clinico-pathological, and therapeutic implications of B-cell proliferation, with or without HCV infection, in MC patients.
2007
7(2)
114
120
C. Ferri; A. Antonelli; M. Mascia;M. Sebastiani; P. Fallahi; D. Ferrari; M. Giunti; S. Pileri; A.L. Zignego;
File in questo prodotto:
File Dimensione Formato  
2007 Ferri Autoimm Rev.pdf

Accesso chiuso

Tipologia: Versione finale referata (Postprint, Accepted manuscript)
Licenza: Tutti i diritti riservati
Dimensione 500.01 kB
Formato Adobe PDF
500.01 kB Adobe PDF   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/318301
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 105
  • ???jsp.display-item.citation.isi??? 81
social impact