Isoxazolidines are reductively cleaved to 1,3-aminoalcohols by reacting with Mo(CO)6 and water. Reaction conditions are simple, mild and selective giving good yields of highly functionalized products with complete retention of configuration of the stereocenters. The reduction fails when steric hindrance is experienced by the nitrogen atom.

1,3-Aminoalcohols by Reductive Cleavage of Isoxazolidines with Molybdenum Hexacarbonyl / S. CICCHI; A. GOTI; A. BRANDI; A. GUARNA; F. DE SARLO. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 31:(1990), pp. 3351-3354. [10.1016/S0040-4039(00)89062-0]

1,3-Aminoalcohols by Reductive Cleavage of Isoxazolidines with Molybdenum Hexacarbonyl

CICCHI, STEFANO;GOTI, ANDREA;BRANDI, ALBERTO;GUARNA, ANTONIO;DE SARLO, FRANCESCO
1990

Abstract

Isoxazolidines are reductively cleaved to 1,3-aminoalcohols by reacting with Mo(CO)6 and water. Reaction conditions are simple, mild and selective giving good yields of highly functionalized products with complete retention of configuration of the stereocenters. The reduction fails when steric hindrance is experienced by the nitrogen atom.
1990
31
3351
3354
S. CICCHI; A. GOTI; A. BRANDI; A. GUARNA; F. DE SARLO
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/319396
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