NMR experiments and tools for the characterization of the structure and dynamics of paramagnetic proteins are presented here. The focus is on the importance of 13C direct-detection NMR for the assignment of paramagnetic systems in solution, on the information contained in paramagnetic effects observed both in solution and in the solid state, and on novel paramagnetism-based tools for the investigation of conformational heterogeneity in protein–protein complexes or in multi-domain proteins.
Perspectives in paramagnetic NMR of metalloproteins / I.Bertini; C.Luchinat; G.Parigi; R.Pierattelli. - In: DALTON TRANSACTIONS. - ISSN 1477-9226. - STAMPA. - 2008:(2008), pp. 3782-3790. [10.1039/b719526e]
Perspectives in paramagnetic NMR of metalloproteins
BERTINI, IVANO;LUCHINAT, CLAUDIO;PARIGI, GIACOMO;PIERATTELLI, ROBERTA
2008
Abstract
NMR experiments and tools for the characterization of the structure and dynamics of paramagnetic proteins are presented here. The focus is on the importance of 13C direct-detection NMR for the assignment of paramagnetic systems in solution, on the information contained in paramagnetic effects observed both in solution and in the solid state, and on novel paramagnetism-based tools for the investigation of conformational heterogeneity in protein–protein complexes or in multi-domain proteins.
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