In the past decade, the potential of harnessing the ability of nuclear magnetic resonance (NMR) spectroscopy to monitor intermolecular interactions as a tool for drug discovery has been increasingly appreciated in academia and industry. In this Perspective, we highlight some of the major applications of NMR in drug discovery, focusing on hit and lead generation, and provide a critical analysis of its current and potential utility.

Perspectives on NMR in drug discovery: a technique comes of age / M.Pellecchia; I.Bertini; D.Cowburn; C.Dalvit; E.Giralt; W.Jahnke; T.L.James; S.W.Homans; H.Kessler; C.Luchinat; B.Meyer; H.Oschkinat; J.Peng; H.Schwalbe; G.Siegal. - In: NATURE REVIEWS DRUG DISCOVERY. - ISSN 1474-1776. - STAMPA. - 7:(2008), pp. 738-745. [10.1038/nrd2606]

Perspectives on NMR in drug discovery: a technique comes of age

BERTINI, IVANO;LUCHINAT, CLAUDIO;
2008

Abstract

In the past decade, the potential of harnessing the ability of nuclear magnetic resonance (NMR) spectroscopy to monitor intermolecular interactions as a tool for drug discovery has been increasingly appreciated in academia and industry. In this Perspective, we highlight some of the major applications of NMR in drug discovery, focusing on hit and lead generation, and provide a critical analysis of its current and potential utility.
2008
7
738
745
M.Pellecchia; I.Bertini; D.Cowburn; C.Dalvit; E.Giralt; W.Jahnke; T.L.James; S.W.Homans; H.Kessler; C.Luchinat; B.Meyer; H.Oschkinat; J.Peng; H.Schwal...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/322051
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