Protein Z is a vitamin K-dependent plasma protein described in its human form in 1984. The amino acid sequence of protein Z shows wide homology with many coagulation factors, such as VII, IX, X, and protein C. However, in contrast to other vitamin K-dependent coagulation factors, protein Z is not a serine protease because of the lack of the active centre in its amino acid sequence. The physiological function of protein Z has been uncertain for many years. In vitro and in vivo studies recently suggested that protein Z plays an important role in inhibiting coagu- lation, as it serves as cofactor for the inactivation of activated factor X by forming a complex with the plasma pro- tein Z-dependent protease inhibitor. The role of alterations of the protein Z levels has been evaluated in different disease states, with conflicting findings. Most of these studies were performed on ischemic vascular diseases. Re- cently, the possible role of protein Z deficiency in the occurrence of cardiovascular diseases has been evaluated.

Protein Z: "Light and Shade" of a new thrombotic factor / F. SOFI; F. CESARI; S. FEDI; R. ABBATE; GF. GENSINI. - In: CLINICAL LABORATORY. - ISSN 1433-6510. - STAMPA. - 50:(2004), pp. 647-652.

Protein Z: "Light and Shade" of a new thrombotic factor

SOFI, FRANCESCO;CESARI, FRANCESCA;FEDI, SANDRA;ABBATE, ROSANNA;GENSINI, GIAN FRANCO
2004

Abstract

Protein Z is a vitamin K-dependent plasma protein described in its human form in 1984. The amino acid sequence of protein Z shows wide homology with many coagulation factors, such as VII, IX, X, and protein C. However, in contrast to other vitamin K-dependent coagulation factors, protein Z is not a serine protease because of the lack of the active centre in its amino acid sequence. The physiological function of protein Z has been uncertain for many years. In vitro and in vivo studies recently suggested that protein Z plays an important role in inhibiting coagu- lation, as it serves as cofactor for the inactivation of activated factor X by forming a complex with the plasma pro- tein Z-dependent protease inhibitor. The role of alterations of the protein Z levels has been evaluated in different disease states, with conflicting findings. Most of these studies were performed on ischemic vascular diseases. Re- cently, the possible role of protein Z deficiency in the occurrence of cardiovascular diseases has been evaluated.
2004
50
647
652
F. SOFI; F. CESARI; S. FEDI; R. ABBATE; GF. GENSINI
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/322149
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