Solid dispersions of ibuprofen in polyethylene glycol (PEG) 20000 were studied by differential thermal and X-ray diffraction analyses. The system was an eutectic mixture with eutectic composition of 40 % ibuprofen and 60% of PEG 20000. The effect of PEG 20000 concentration on the ibuprofen solubility in water was determined. The influence of the drug-PEG ratio on the drug dissolution rate was also determined.

Phase equilibria, crystallinity and dissolution rates of ibuprofen-polyethylene glycol 20000 solid dispersions / P. Mura; A. Liguori; G. Bramanti; L. Poggi. - In: IL FARMACO. EDIZIONE PRATICA. - ISSN 0430-0912. - STAMPA. - 42:(1987), pp. 157-164.

Phase equilibria, crystallinity and dissolution rates of ibuprofen-polyethylene glycol 20000 solid dispersions

MURA, PAOLA ANGELA;LIGUORI, ANTONELLA UGHETTA;BRAMANTI, GIAMPIERO;POGGI, LUISA
1987

Abstract

Solid dispersions of ibuprofen in polyethylene glycol (PEG) 20000 were studied by differential thermal and X-ray diffraction analyses. The system was an eutectic mixture with eutectic composition of 40 % ibuprofen and 60% of PEG 20000. The effect of PEG 20000 concentration on the ibuprofen solubility in water was determined. The influence of the drug-PEG ratio on the drug dissolution rate was also determined.
1987
42
157
164
P. Mura; A. Liguori; G. Bramanti; L. Poggi
1a - Articolo su rivista
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/324066
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