The human tachykinin NK-2 (hNK-2) receptor is considered a promising target for relevant pathologies at the respiratory, gastrointestinal and genitourinary level. With the aim of reducing the complexity of existing peptide antagonists, two series of hNK-2 receptor antagonists were designed, with the support of modelling, and synthesized. The X-ray structure determination of two compounds, each belonging to one of the two series, allowed the experimental validation of the initial rationale. In addition, it has been found that the two series share a -turn structure, a key feature for binding the hNK-2 receptor.
New monocyclic and acyclic hNK-2 antagonists retaining the beta -turn feature. X-ray and molecular modelling studies / M. Altamura; P. Dapporto; V. Fedi; A. Giolitti; A. Guerri; A. Guidi; C. A. Maggi; P. Paoli; P. Rossi. - In: ACTA CRYSTALLOGRAPHICA. SECTION B, STRUCTURAL SCIENCE. - ISSN 0108-7681. - STAMPA. - B62:(2006), pp. 889-896. [10.1107/S0108768106018167]
New monocyclic and acyclic hNK-2 antagonists retaining the beta -turn feature. X-ray and molecular modelling studies
DAPPORTO, PAOLO;GUERRI, ANNALISA;PAOLI, PAOLA;ROSSI, PATRIZIA
2006
Abstract
The human tachykinin NK-2 (hNK-2) receptor is considered a promising target for relevant pathologies at the respiratory, gastrointestinal and genitourinary level. With the aim of reducing the complexity of existing peptide antagonists, two series of hNK-2 receptor antagonists were designed, with the support of modelling, and synthesized. The X-ray structure determination of two compounds, each belonging to one of the two series, allowed the experimental validation of the initial rationale. In addition, it has been found that the two series share a -turn structure, a key feature for binding the hNK-2 receptor.
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