Previous studies showed that a multi-component system obtained by co-grinding of dehydroepiandrosterone (DHEA) with α-cyclodextrin (α-Cd) and glycine allowed a significant improvement of DHEA dissolution and bioavailability. Further studies were then performed in the present work to characterize such ternary system in depth and evaluate the role of the cyclodextrin type, the presence of glycine, and the component’s molar ratio on the system performance. The results proved the greater effectiveness of α-Cd than β-Cd in inducing DHEA amorphization by cogrinding and the efficacy of glycine in favouring this effect. The ternary system DHEA/α-Cd/glycine in the 1:2:3 molar ratio was the optimal combination to achieve complete drug amorphization and optimal dissolution behaviour
Physicochemical characterization of DHEA-cyclodextrin-glycine ternary systems / P. Corvi Mora; M. Cirri; F. Carli; P. Mura. - STAMPA. - (2004), pp. 471-474. (Intervento presentato al convegno 12th International Cyclodextrin Symposium tenutosi a Montpellier nel 16-19/05/2004).
Physicochemical characterization of DHEA-cyclodextrin-glycine ternary systems
CIRRI, MARZIA;MURA, PAOLA ANGELA
2004
Abstract
Previous studies showed that a multi-component system obtained by co-grinding of dehydroepiandrosterone (DHEA) with α-cyclodextrin (α-Cd) and glycine allowed a significant improvement of DHEA dissolution and bioavailability. Further studies were then performed in the present work to characterize such ternary system in depth and evaluate the role of the cyclodextrin type, the presence of glycine, and the component’s molar ratio on the system performance. The results proved the greater effectiveness of α-Cd than β-Cd in inducing DHEA amorphization by cogrinding and the efficacy of glycine in favouring this effect. The ternary system DHEA/α-Cd/glycine in the 1:2:3 molar ratio was the optimal combination to achieve complete drug amorphization and optimal dissolution behaviour
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