The effect of cyclodextrins and chitosan, separately or in combination, on the dissolution properties and permeability through intestinal epithelial cells (Caco-2) of glyburide, (an oral hypoglycemic agent subject to incomplete and variable bioavailability) has been evaluated. When using the carriers together a possible competition effect has been observed in solubility studies and, by contrast, a synergistic effect was revealed in permeation experiments.
Effects of cyclodextrins and chitosan on gliburide dissolution and permeability through intestinal epithelial cells (Caco 2) / N. Zerrouk; S. Ancillotti; F. Maestrelli; M. Cirri; P. Mura. - STAMPA. - (2004), pp. 871-874. (Intervento presentato al convegno 12th International Cyclodextrin Symposium tenutosi a Montpellier nel 16-19/05/2004).