In the circular muscle of the rabbit gastric corpus, the nitric oxide-synthesis inhibitor L-NG-nitro arginine (L-NOARG), enhanced the neurally-induced cholinergic responses evoked by electrical field stimulation (EFS) and ganglionic stimulating agents (nicotine, dimethylphenyl piperazinium iodide). The muscular contractions caused by acetylcholine (Ach) and methacholine were not influenced by the nitric oxide-synthesis inhibitor. The nitric oxide-releasing compound sodium nitroprusside (SNP) did not affect the Ach-induced muscular responses. Our results suggest that L-NOARG enhances gastric cholinergic responses by removing an inhibitory influence exerted at the prejunctional level in the nerve-muscle pathway.

Effects of L-ng-nitro arginine on cholinergic transmission in the gastric muscle of the rabbit / M. Baccari; M. Bertini; F. Calamai. - In: NEUROREPORT. - ISSN 0959-4965. - STAMPA. - 4:(1993), pp. 1102-1104.

Effects of L-ng-nitro arginine on cholinergic transmission in the gastric muscle of the rabbit

BACCARI, MARIA CATERINA;CALAMAI, FRANCO
1993

Abstract

In the circular muscle of the rabbit gastric corpus, the nitric oxide-synthesis inhibitor L-NG-nitro arginine (L-NOARG), enhanced the neurally-induced cholinergic responses evoked by electrical field stimulation (EFS) and ganglionic stimulating agents (nicotine, dimethylphenyl piperazinium iodide). The muscular contractions caused by acetylcholine (Ach) and methacholine were not influenced by the nitric oxide-synthesis inhibitor. The nitric oxide-releasing compound sodium nitroprusside (SNP) did not affect the Ach-induced muscular responses. Our results suggest that L-NOARG enhances gastric cholinergic responses by removing an inhibitory influence exerted at the prejunctional level in the nerve-muscle pathway.
1993
4
1102
1104
Goal 3: Good health and well-being for people
M. Baccari; M. Bertini; F. Calamai
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/328780
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