Pyridoxamine inhibits rabbit and pig plasma benzylamine oxidase (BAO), the diamine oxidase of pig kidney and the lysyloxidase of pig aorta in-vitro. In-vivo in the rabbit, the inhibitory activity of pyridoxamine on plasma BAO is antagonized by an increase in the level of this enzyme that is dependent on an increase in rate of synthesis, there being no variation in the degradation rate constant.
Pyridoxamine as inhibitor of the blood plasma benzylamine oxidase and other copper-containing amine oxidases / F. Buffoni; G. Banchelli; P. Dolara; G. Ignesti; R. Pirisino; L. Raimondi; M. Ziche. - In: JOURNAL OF PHARMACY AND PHARMACOLOGY. - ISSN 0022-3573. - STAMPA. - 37:(1985), pp. 597-600.
Pyridoxamine as inhibitor of the blood plasma benzylamine oxidase and other copper-containing amine oxidases.
BUFFONI, FRANCA;BANCHELLI, MARIA GRAZIA;DOLARA, PIERO;PIRISINO, RENATO GIOVANNI PAOLO;RAIMONDI, LAURA;
1985
Abstract
Pyridoxamine inhibits rabbit and pig plasma benzylamine oxidase (BAO), the diamine oxidase of pig kidney and the lysyloxidase of pig aorta in-vitro. In-vivo in the rabbit, the inhibitory activity of pyridoxamine on plasma BAO is antagonized by an increase in the level of this enzyme that is dependent on an increase in rate of synthesis, there being no variation in the degradation rate constant.
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