The present data add to the growing body of information that common allelic variants in promoter regions of genes encoding for molecules involved in either the innate (CD14) or adoptive (CTLA-4) immune reactions are associated with an increased risk of GVHD after allogeneic stem cell transplantation. Prospectively, these molecules represent potential targets for novel therapeutic interventions.
Significance of CTLA-4 and CD14 genetic polymorphisms in clinical outcome after allogeneic stem cell transplantation / A. M. Vannucchi; S. Guidi; P. Guglielmelli; S. Glinz; L. Lombardini; A. Busca; F. Locatelli; A. M. Dall'Omo; A. Bosi. - In: BONE MARROW TRANSPLANTATION. - ISSN 0268-3369. - STAMPA. - 40:(2007), pp. 1001-1002. [10.1038/sj.bmt.1705850]
Significance of CTLA-4 and CD14 genetic polymorphisms in clinical outcome after allogeneic stem cell transplantation.
VANNUCCHI, ALESSANDRO MARIA;GUGLIELMELLI, PAOLA;BOSI, ALBERTO
2007
Abstract
The present data add to the growing body of information that common allelic variants in promoter regions of genes encoding for molecules involved in either the innate (CD14) or adoptive (CTLA-4) immune reactions are associated with an increased risk of GVHD after allogeneic stem cell transplantation. Prospectively, these molecules represent potential targets for novel therapeutic interventions.
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