Abstract: Monocytes are able to specifically bind heparin rapidly, reversibly, and saturably with 5.5 +/- 2.6 X 10(6) binding sites per monocyte and a dissociation constant of 330 +/- 221 nmol/l. Moreover, at least 40-50% of the cell-bound heparin can be internalized. Heparin binding by monocytes is affected by cell stimulation with an increase of the availability of binding sites after challenge with calcium ionophore, lipopolysaccharide, and interleukin 2. The interaction of heparin with monocytes reversibly decreases the expression of tissue factor on the cellular surface, so hampering the cellular procoagulant potential.
Heparin, monocytes, and procoagulant activity / R.Abbate; AM.Gori; PA.Modesti; M.Attanasio; F.Martini; A.Colella; B.Giusti; I.Cecioni; GG.Neri Serneri. - In: HAEMOSTASIS. - ISSN 0301-0147. - STAMPA. - 20:(1990), pp. 98-100.
Heparin, monocytes, and procoagulant activity
ABBATE, ROSANNA;GORI, ANNA MARIA;MODESTI, PIETRO AMEDEO;ATTANASIO, MONICA;GIUSTI, BETTI;CECIONI, ILARIA;NERI SERNERI, GIAN GASTONE
1990
Abstract
Abstract: Monocytes are able to specifically bind heparin rapidly, reversibly, and saturably with 5.5 +/- 2.6 X 10(6) binding sites per monocyte and a dissociation constant of 330 +/- 221 nmol/l. Moreover, at least 40-50% of the cell-bound heparin can be internalized. Heparin binding by monocytes is affected by cell stimulation with an increase of the availability of binding sites after challenge with calcium ionophore, lipopolysaccharide, and interleukin 2. The interaction of heparin with monocytes reversibly decreases the expression of tissue factor on the cellular surface, so hampering the cellular procoagulant potential.
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