Pathogens can induce autoreactive T cells to initiate autoimmune disease by several mechanisms. Pathogen-induced inflammation results in the enhanced presentation of self antigens, which causes the expansion of the activated autoreactive T cells that are required for disease onset. Alternatively, a pathogen might express antigens with epitopes that are structurally similar to epitopes of autoantigens, resulting in a mechanism of molecular mimicry. This is the case for Helicobacter pylori-associated human autoimmune gastritis, in which the activated CD4+ Th1 cells that infiltrate the gastric mucosa cross-recognize the epitopes of self gastric parietal cell H(+)K(+)-ATPase and of various H. pylori proteins. Therefore, in genetically susceptible individuals, H. pylori infection can start or worsen gastric autoimmunity, leading to atrophic gastritis.

Gastric autoimmunity: The role of Helicobacter pylori and molecular mimicry / D'ELIOS M.M.; APPELMELK B.J.; AMEDEI A.; BERGMAN M.P.; G. DEL PRETE. - In: TRENDS IN MOLECULAR MEDICINE. - ISSN 1471-4914. - STAMPA. - 10:(2004), pp. 316-323. [10.1016/j.molmed.2004.06.001]

Gastric autoimmunity: The role of Helicobacter pylori and molecular mimicry

D'ELIOS, MARIO MILCO;AMEDEI, AMEDEO;DEL PRETE, GIANFRANCO
2004

Abstract

Pathogens can induce autoreactive T cells to initiate autoimmune disease by several mechanisms. Pathogen-induced inflammation results in the enhanced presentation of self antigens, which causes the expansion of the activated autoreactive T cells that are required for disease onset. Alternatively, a pathogen might express antigens with epitopes that are structurally similar to epitopes of autoantigens, resulting in a mechanism of molecular mimicry. This is the case for Helicobacter pylori-associated human autoimmune gastritis, in which the activated CD4+ Th1 cells that infiltrate the gastric mucosa cross-recognize the epitopes of self gastric parietal cell H(+)K(+)-ATPase and of various H. pylori proteins. Therefore, in genetically susceptible individuals, H. pylori infection can start or worsen gastric autoimmunity, leading to atrophic gastritis.
2004
10
316
323
D'ELIOS M.M.; APPELMELK B.J.; AMEDEI A.; BERGMAN M.P.; G. DEL PRETE
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/333278
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