Primary leiomyosarcoma of the pancreas is a rare tumor for which only 21 reports appear in the world literature. We describe an additional case of pancreatic leiomyosarcoma in a 76-year-old man, who complained of persistent high fever. Histologic examination revealed a pleomorphic spindle cell tumor. Reactivity for muscle-specific actin, a smooth muscle actin, and basement membrane components, along with negative staining for epithelial and neural markers, were consistent with a smooth muscle sarcoma. The patient died of disease 1 year after complete surgical excision. This report highlights the need to use a complete antibody panel in order to accurately immunophenotype pleomorphic malignant tumors of the pancreas. A review of the cases compiled in the literature indicates that pancreatic leiomyosarcoma, like its counterpart arising in deep soft tissues, is an aggressive neoplasm characterized by short survival and a high rate of metastases.

PRIMARY LEIOMYOSARCOMA OF THE PANCREAS: A CASE REPORT WITH REVIEW OF THE LITERATURE / G. NESI; D. PANTALONE; I. RAGIONIERI; A. AMOROSI. - In: ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE. - ISSN 0003-9985. - STAMPA. - 125:(2001), pp. 152-155.

PRIMARY LEIOMYOSARCOMA OF THE PANCREAS: A CASE REPORT WITH REVIEW OF THE LITERATURE

NESI, GABRIELLA
Writing – Review & Editing
;
PANTALONE, DESIRE'
Validation
;
AMOROSI, ANDREA
Writing – Original Draft Preparation
2001

Abstract

Primary leiomyosarcoma of the pancreas is a rare tumor for which only 21 reports appear in the world literature. We describe an additional case of pancreatic leiomyosarcoma in a 76-year-old man, who complained of persistent high fever. Histologic examination revealed a pleomorphic spindle cell tumor. Reactivity for muscle-specific actin, a smooth muscle actin, and basement membrane components, along with negative staining for epithelial and neural markers, were consistent with a smooth muscle sarcoma. The patient died of disease 1 year after complete surgical excision. This report highlights the need to use a complete antibody panel in order to accurately immunophenotype pleomorphic malignant tumors of the pancreas. A review of the cases compiled in the literature indicates that pancreatic leiomyosarcoma, like its counterpart arising in deep soft tissues, is an aggressive neoplasm characterized by short survival and a high rate of metastases.
2001
125
152
155
Goal 3: Good health and well-being
G. NESI; D. PANTALONE; I. RAGIONIERI; A. AMOROSI
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/335145
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