Primary leiomyosarcoma of the pancreas is a rare tumor for which only 21 reports appear in the world literature. We describe an additional case of pancreatic leiomyosarcoma in a 76-year-old man, who complained of persistent high fever. Histologic examination revealed a pleomorphic spindle cell tumor. Reactivity for muscle-specific actin, a smooth muscle actin, and basement membrane components, along with negative staining for epithelial and neural markers, were consistent with a smooth muscle sarcoma. The patient died of disease 1 year after complete surgical excision. This report highlights the need to use a complete antibody panel in order to accurately immunophenotype pleomorphic malignant tumors of the pancreas. A review of the cases compiled in the literature indicates that pancreatic leiomyosarcoma, like its counterpart arising in deep soft tissues, is an aggressive neoplasm characterized by short survival and a high rate of metastases.
PRIMARY LEIOMYOSARCOMA OF THE PANCREAS: A CASE REPORT WITH REVIEW OF THE LITERATURE / G. NESI; D. PANTALONE; I. RAGIONIERI; A. AMOROSI. - In: ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE. - ISSN 0003-9985. - STAMPA. - 125:(2001), pp. 152-155.
PRIMARY LEIOMYOSARCOMA OF THE PANCREAS: A CASE REPORT WITH REVIEW OF THE LITERATURE
NESI, GABRIELLAWriting – Review & Editing
;PANTALONE, DESIRE'Validation
;AMOROSI, ANDREAWriting – Original Draft Preparation
2001
Abstract
Primary leiomyosarcoma of the pancreas is a rare tumor for which only 21 reports appear in the world literature. We describe an additional case of pancreatic leiomyosarcoma in a 76-year-old man, who complained of persistent high fever. Histologic examination revealed a pleomorphic spindle cell tumor. Reactivity for muscle-specific actin, a smooth muscle actin, and basement membrane components, along with negative staining for epithelial and neural markers, were consistent with a smooth muscle sarcoma. The patient died of disease 1 year after complete surgical excision. This report highlights the need to use a complete antibody panel in order to accurately immunophenotype pleomorphic malignant tumors of the pancreas. A review of the cases compiled in the literature indicates that pancreatic leiomyosarcoma, like its counterpart arising in deep soft tissues, is an aggressive neoplasm characterized by short survival and a high rate of metastases.File | Dimensione | Formato | |
---|---|---|---|
Leiomiosarcoma pancreas_0001.pdf
accesso aperto
Descrizione: si descrive la insorgenza di un leiosarcoma primitivo del pancreas, con ampia revisione della letteratura
Tipologia:
Pdf editoriale (Version of record)
Licenza:
Open Access
Dimensione
1.91 MB
Formato
Adobe PDF
|
1.91 MB | Adobe PDF |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.