JAK2V617F mutational status and allele burden have little influence on clinical phenotype and prognosis in patients with post-polycythemia vera and post-essential thrombocythemia myelofibrosis

this is the first study specifically addressing the clinical relevance of JAK2V617F mutation in patients who evolved to MF from a previous PV or ET. The data presented herein prompted us to conclude that neither the JAK2V617F mutational status nor the V617F allele burden seem to have relevance for disease phenotype or prognosis in this setting of patients. However, the relatively short follow-up might have prevented the discovery of correlations of JAK2V617F mutational status with clinical events occurring late in the history of these disorders, in particular for the evolution to AML. This will require larger patient series with a much longer observation.