Superfusion of guinea-pig atria with 10 mM l-leucine methylester leads to a mechanical arrest and to an increase in protein outflow. Homogenate of atria exhibits a decrease in the sedimentability of phosphatase acid activity as compared to control. Morphological studies reveal that leucine methylester causes not only a lysosomal swelling but also a disruption of myofibrils and slight mitochondrial damage.
Effects of leucine methylester on guinea-pig atria / Franconi F; Bennardini F; Stendardi I; Matucci R; Dini G; Giotti A. - In: ACTA PHARMACOLOGICA ET TOXICOLOGICA. - ISSN 0001-6683. - STAMPA. - 57:(1985), pp. 141-146.
Effects of leucine methylester on guinea-pig atria.
FRANCONI, FLAVIA;STENDARDI, ISABELLA;MATUCCI, ROSANNA;DINI, GERMANA;GIOTTI, ALBERTO
1985
Abstract
Superfusion of guinea-pig atria with 10 mM l-leucine methylester leads to a mechanical arrest and to an increase in protein outflow. Homogenate of atria exhibits a decrease in the sedimentability of phosphatase acid activity as compared to control. Morphological studies reveal that leucine methylester causes not only a lysosomal swelling but also a disruption of myofibrils and slight mitochondrial damage.
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