The thickness of eosinophilic band in collagenous colitis (CC) was assessed by 3 methods: histologic estimates (22 observers), conventional measurements using a calibrated micrometric scale (1 observer), and semiautomatic micrometric measurements (1 observer). By the histologic estimate technique, 7.4% of the results failed to diagnose CC; by calibrated micrometry, the failure was 6% and by semiautomatic micrometry, 6%. The main difficulty in measuring the thickness of the CC band is that the deeper border of the band appears fuzzy and hairy-irregular. CC should be defined not exclusively on the basis of the thickness of the collagen table, but as a microscopic constellation characterized by a distorted superficial cell arrangement, with areas of epithelial denudation and inflammatory cells in the superficial epithelium and the lamina propria. In agreement with Lazenby’s statement: “Focusing solely on the collagen band can result in both over- and underdiagnosis.”
Quantitative assessment of the subepithelial collagen band does not increase the accuracy of diagnosis of collagenous colitis / Carlos A Rubio; Abiel Orrego; Anders Höög; Anja Porwitz; Fredrik Petersson; Göran Elmberger; Axel Glaessgen; Elina Eriksson; Lena Kanter; Georg Jaremko; Lars Egevad; Juan Laforga; M. Liljefors; Britta Löfdahl; Peter Norman; Olle Larsson; Robert Wanat; Johan Wejde; Peter Zickert; Jan Björk; Saverio Caini; Domenico Palli; Gabriella Nesi. - In: AMERICAN JOURNAL OF CLINICAL PATHOLOGY. - ISSN 0002-9173. - STAMPA. - 130:(2008), pp. 375-381.
Quantitative assessment of the subepithelial collagen band does not increase the accuracy of diagnosis of collagenous colitis.
NESI, GABRIELLA
2008
Abstract
The thickness of eosinophilic band in collagenous colitis (CC) was assessed by 3 methods: histologic estimates (22 observers), conventional measurements using a calibrated micrometric scale (1 observer), and semiautomatic micrometric measurements (1 observer). By the histologic estimate technique, 7.4% of the results failed to diagnose CC; by calibrated micrometry, the failure was 6% and by semiautomatic micrometry, 6%. The main difficulty in measuring the thickness of the CC band is that the deeper border of the band appears fuzzy and hairy-irregular. CC should be defined not exclusively on the basis of the thickness of the collagen table, but as a microscopic constellation characterized by a distorted superficial cell arrangement, with areas of epithelial denudation and inflammatory cells in the superficial epithelium and the lamina propria. In agreement with Lazenby’s statement: “Focusing solely on the collagen band can result in both over- and underdiagnosis.”File | Dimensione | Formato | |
---|---|---|---|
ID 347510.pdf
Accesso chiuso
Tipologia:
Versione finale referata (Postprint, Accepted manuscript)
Licenza:
Tutti i diritti riservati
Dimensione
3.93 MB
Formato
Adobe PDF
|
3.93 MB | Adobe PDF | Richiedi una copia |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.