The role of modern pharmacology has changed profoundly in recent years and can make an important contribution to improving antibiotic use. Prior to the ‘90s, intervention by the pharmacologist was limited to studying pharmacokinetics. Successively, when a correlation between plasma or tissue levels of an antibiotic and its pharmacological activity was determined, pharmacodynamic parameters, such as the minimum inhibitory concentration (MIC), the minimum bactericidal concentration, the different types of bacterial killing, the post-antibiotic effect and the effect of subinhibitory concentrations had become important. These tools available to the pharmacologist were accompanied, at least for some antibiotic classes, by a new parameter: the concentration that can prevent mutations (Mutant Prevention Concentration, MPC), which is defined as the MIC of the first resistant mutant bacteria in a heterogeneous population or as the lowest concentration able to prevent the growth of resistant mutants.
How pharmacokinetic-pharmacodynamic (PK-PD) parameters influence antibiotic use / T. Mazzei. - In: JOURNAL OF CHEMOTHERAPY. - ISSN 1120-009X. - STAMPA. - 20 (Cong. Rep. 2):(2006), pp. 19-21.
How pharmacokinetic-pharmacodynamic (PK-PD) parameters influence antibiotic use
MAZZEI, TERESITA
2006
Abstract
The role of modern pharmacology has changed profoundly in recent years and can make an important contribution to improving antibiotic use. Prior to the ‘90s, intervention by the pharmacologist was limited to studying pharmacokinetics. Successively, when a correlation between plasma or tissue levels of an antibiotic and its pharmacological activity was determined, pharmacodynamic parameters, such as the minimum inhibitory concentration (MIC), the minimum bactericidal concentration, the different types of bacterial killing, the post-antibiotic effect and the effect of subinhibitory concentrations had become important. These tools available to the pharmacologist were accompanied, at least for some antibiotic classes, by a new parameter: the concentration that can prevent mutations (Mutant Prevention Concentration, MPC), which is defined as the MIC of the first resistant mutant bacteria in a heterogeneous population or as the lowest concentration able to prevent the growth of resistant mutants.I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.