The paper describes a method able to perform an ultrasonic study of a single UCA bubble immersed in a tank filled with a liquid (water) by means of ultrasonic equipment able to insonify and acquire RF echo signals coming from an isolated bubble with a high frame rate. The work was focused on the study of subharmonic emission from an isolated bubble of SonoVue. In particular, the acoustic pressure threshold for a subharmonic stable emission was evaluated for a subset of 50 microbubbles at 3.3 MHz and at 5 MHz of insonation frequencies. An unexpected second pressure threshold, which caused the standstill of the subharmonic emission, was detected at 3.3 MHz and 5 MHz. A transient subharmonic emission, which is hypothesized as being related to the formation of new free gas bubbles, was detected during the ultrasound-induced destruction of microbubbles. Specific bubble behaviors concerning the stable subharmonic emission, the inhibition of subharmonic generation, and the transient subharmonic emission were investigated over a set of 400 isolated microbubbles and experimental results are reported and discussed in this paper.

Ultrasound Contrast Agent Microbubbles: Stable and Transient Subharmonic Emissions / L. Masotti; E. Biagi; L. Breschi; E. Vannacci. - STAMPA. - 122-n°5:(2007), pp. 3051-3052. (Intervento presentato al convegno Acoustical Society of America Meeting tenutosi a New Orleans, Louisiana).

Ultrasound Contrast Agent Microbubbles: Stable and Transient Subharmonic Emissions.

MASOTTI, LEONARDO;BIAGI, ELENA;BRESCHI, LUCA;VANNACCI, ENRICO
2007

Abstract

The paper describes a method able to perform an ultrasonic study of a single UCA bubble immersed in a tank filled with a liquid (water) by means of ultrasonic equipment able to insonify and acquire RF echo signals coming from an isolated bubble with a high frame rate. The work was focused on the study of subharmonic emission from an isolated bubble of SonoVue. In particular, the acoustic pressure threshold for a subharmonic stable emission was evaluated for a subset of 50 microbubbles at 3.3 MHz and at 5 MHz of insonation frequencies. An unexpected second pressure threshold, which caused the standstill of the subharmonic emission, was detected at 3.3 MHz and 5 MHz. A transient subharmonic emission, which is hypothesized as being related to the formation of new free gas bubbles, was detected during the ultrasound-induced destruction of microbubbles. Specific bubble behaviors concerning the stable subharmonic emission, the inhibition of subharmonic generation, and the transient subharmonic emission were investigated over a set of 400 isolated microbubbles and experimental results are reported and discussed in this paper.
2007
The Journal of the Acoustical Society of America
Acoustical Society of America Meeting
New Orleans, Louisiana
L. Masotti; E. Biagi; L. Breschi; E. Vannacci
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/357358
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