Abstract: We have optimized previously discovered benzoic acids 1, which are active as inhibitors of PTP1B and LMW-PTP, two protein tyrosine phosphatases that have emerged as attractive targets for the development of novel therapeutic agents for the treatment of diabetes, obesity, and cancer. Our efforts led to the identification of new and more potent analogues with appreciable selectivity toward human PTP1B and the IF1 isoform of human LMW-PTP.

Structure-Based Optimization of Benzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B and Low Molecular Weight Protein Tyrosine Phosphatase / R. Maccari; R. Ottanà; R. Ciurleo; P. Paoli; G. Manao; G. Camici; C. Laggner; T. Langer. - In: CHEMMEDCHEM. - ISSN 1860-7179. - STAMPA. - 4(2009), pp. 957-962. [10.1002/cmdc.200800427]

Structure-Based Optimization of Benzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B and Low Molecular Weight Protein Tyrosine Phosphatase

PAOLI, PAOLO;MANAO, GIAMPAOLO;CAMICI, GUIDO;
2009

Abstract

Abstract: We have optimized previously discovered benzoic acids 1, which are active as inhibitors of PTP1B and LMW-PTP, two protein tyrosine phosphatases that have emerged as attractive targets for the development of novel therapeutic agents for the treatment of diabetes, obesity, and cancer. Our efforts led to the identification of new and more potent analogues with appreciable selectivity toward human PTP1B and the IF1 isoform of human LMW-PTP.
4
957
962
R. Maccari; R. Ottanà; R. Ciurleo; P. Paoli; G. Manao; G. Camici; C. Laggner; T. Langer
File in questo prodotto:
File Dimensione Formato  
ID 357681 chemmedchem09.pdf

Accesso chiuso

Tipologia: Versione finale referata (Postprint, Accepted manuscript)
Licenza: DRM non definito
Dimensione 542.73 kB
Formato Adobe PDF
542.73 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/357681
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact