Type 17 Th (Th17) cells have been identified as a distinct population of CD4+ effector T cells different from Th1 and Th2 cells. While the pre-eminent cytokine of Th1 cells is IFN-γ and that of Th2 cells is IL-4, the distinctive cytokine of Th17 cells is IL-17A. However, although murine and human Th1 and Th2 cells exhibit strong similarities, human and murine Th17 cells seem to differ in several aspects.
Human Th17 cells: are they different from murine Th17 cells? / F.Annunziato; L.Cosmi; F.Liotta; E.Maggi; S.Romagnani. - In: EUROPEAN JOURNAL OF IMMUNOLOGY. - ISSN 0014-2980. - STAMPA. - 39:(2009), pp. 637-640. [10.1002/eji.200839050]
Human Th17 cells: are they different from murine Th17 cells?
ANNUNZIATO, FRANCESCO;COSMI, LORENZO;LIOTTA, FRANCESCO;MAGGI, ENRICO;ROMAGNANI, SERGIO
2009
Abstract
Type 17 Th (Th17) cells have been identified as a distinct population of CD4+ effector T cells different from Th1 and Th2 cells. While the pre-eminent cytokine of Th1 cells is IFN-γ and that of Th2 cells is IL-4, the distinctive cytokine of Th17 cells is IL-17A. However, although murine and human Th1 and Th2 cells exhibit strong similarities, human and murine Th17 cells seem to differ in several aspects.
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