Antibiotic usage and risk of colonization and infection with antibiotic-resistant bacteria: a hospital population-based study

Tacconelli, Evelina; Giulia De Angelis,; Maria Adriana Cataldo,; Mantengoli, Elisabetta; Spanu, Teresa; Pan, Angelo; Corti, Giampaolo; Radice, Anna; Stolzuoli, Lucia; Antinori, Spinello; Paradisi, Franco; Carosi, Giampiero; Bernabei, Roberto; Antonelli, Massimo; Fadda, Giovanni; Rossolini, Gian Maria; Cauda, Roberto

doi:10.1128/AAC.00431-09

Accurate assessment of risk factors for nosocomial acquisition of colonization by antibiotic-resistant bacteria (ARB) is often confounded by scarce data on antibiotic use. A 12-month, nested, multicenter cohort study was conducted. Target ARB were methicillin (meticillin)-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and ciprofloxacin-resistant Pseudomonas aeruginosa (CR-PA). Identifying ARB colonization early during antibiotic therapy could target a high-risk hospitalized population that may benefit from intervention to decrease the risk of subsequent nosocomial infections.

Antibiotic usage and risk of colonization and infection with antibiotic-resistant bacteria: a hospital population-based study / Evelina Tacconelli, Giulia De Angelis, Maria Adriana Cataldo, Elisabetta Mantengoli, Teresa Spanu, Angelo Pan, Giampaolo Corti, Anna Radice, Lucia Stolzuoli, Spinello Antinori, Franco Paradisi, Giampiero Carosi, Roberto Bernabei, Massimo Antonelli, Giovanni Fadda, Gian Maria Rossolini, Roberto Cauda. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - STAMPA. - 53:(2009), pp. 4264-4269. [10.1128/AAC.00431-09]